Народився 9 березня 1814 року у селі Моринці Звенигородського повіту Київської губернії в закріпаченій селянській родині. Дитячі роки проходять у селі Керелівка.
Восени 1822 року починає вчитися грамоти у місцевого дяка. Залишившись сиротою, іде наймитувати до дяка Богорського, який прибув з Києва. Не витерпівши знущань дяка, тікає від нього і шукає в навколишніх селах учителя-маляра.
1828 року взяли козачком (слугою) до панського двору у с. Вільшану. Упродовж майже 2,5 років — з осені 1828 року до початку 1831 р. — Шевченко пробув зі своїм паном у Вільні. Переїхавши 1831 року з Вільно до Петербурга, Енгельгардт взяв із собою Шевченка і віддав його в науку на 4 роки до живописця Василя Ширяєва.
Улітку 1836 р. він познайомився зі своїм земляком — художником І. Сошенком, а через нього — з Євгеном Гребінкою, В. Григоровичем і О. Венеціановим.
Навесні 1838 Карл Брюллов та Василь Жуковський викупили молодого поета з кріпацтва. Незабаром став студентом Академії мистецтв. Першу збірку своїх поетичних творів видав 1840 під назвою «Кобзар».
25 травня 1843 року з Петербурга виїхав в Україну.
В лютому 1844 року виїхав з України до Петербурга через Москву.
У 1844р. написав гостро політичну поему «Сон» («У всякого своя доля»), ставши на шлях безкомпромісної боротьби проти самодержавної системи тодішньої Російської Імперії. 5 квітня рада Академії мистецтв видала квиток на право проїзду на Україну.
Вже в листопаді 1845 року збори Академії мистецтв у Петербурзі затвердили рішення ради про надання звання некласного художника. 31 березня (12 квітня) 1845 року виїхав із Петербурга через Москву до Києва.
Навесні 1846 року прибув до Києва, оселився в будинку. У квітні пристав до Кирило-Мефодіївського братства. Заарештували 5 квітня 1847, відправили до Петербурга й ув’язнили в казематі. Заслали в солдати до Оренбурга. Деяке полегшення становища Шевченка настало навесні 1848 унаслідок включення його до складу Аральської експедиції.
У квітні 1850 Шевченка вдруге заарештовано і, після піврічного ув’язнення, запроторено в Новопетровський береговий форт. Звільнено з заслання у 1857 р.
Навесні 1858 поет прибув до Петербурга.
Влітку 1859 року повернувся в Україну, якої вже 12 років не бачив. До останніх днів свого життя поет перебував під таємним поліційним наглядом.
10 березня 1861 року Шевченко помер.
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